National institute of diabetes and digestive and kidney diseases, bethesda md. Generic metaxalone is covered by some medicare and insurance plans, but manufacturer and pharmacy. Learn about side effects, drug interactions, dosages, warnings, and more. Metaxalone is the generic name of the prescription drug skelaxin, which is used to relax tense muscles and relieve pain from muscle spasms. Metaxalone oral skelaxin side effects, medical uses, and. I am on inderal, topamax, skelaxin, maxalt mlt plus the narcotics that are still sometimes needed from time to time. It is known to cause an elevation in the cephalin flocculation test, necessitating serial liver function assessments. Can people with kidney disease take skelaxin metaxalone. Skelaxin side effects, uses, dosage, overdose, pregnancy. When calculating the maximum daily dose, consider all sources of acetaminophen, including otc, and routes of administration not to exceed the.
Metaxalone is a skeletal muscle relaxant prescribed for the shortterm treatment of painful muscle spasms. Skelaxin metaxalone clinical pharmacology pfizer medical. The dose of this medicine will be different for different patients. Feb 26, 2019 skelaxin metaxalone is available as an 800 mg oval, scored pink tablet inscribed with 8667 on the scored side and s on the other. The following information includes only the average doses of this medicine. Skelaxin metaxalone dosing, indications, interactions, adverse. The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Skelaxin belongs to a group of drugs called muscle relaxants. The recommended dose for adults and children over 12 years of age is one 800 mg tablet three to four times a day. Doubling the dose of skelaxin from 400 mg to 800 mg results in a roughly proportional increase in metaxalone exposure as indicated by peak plasma concentrations cmax and area under the curve auc.
Skelaxin is one of several types of drugs in the class of muscle relaxants. Doubling the dose of skelaxin from 400 mg to 800 mg concentrations c and area under the curve auc. Take this medication by mouth with or without food as directed by your doctor. Skelaxin dosing information usual adult dose for muscle spasm. Food effects a randomized, twoway, crossover study was conducted in 42 healthy volunteers 31 males, 11 females administered one 400 mg skelaxin tablet under fasted conditions and following a standard highfat breakfast. For more information and to be sure skelaxin is the right drug for you. Sep 03, 20 skelaxin is a prescription medication used to treat muscle pain. Metaxalone belongs to a group of medications called. Skelaxin metaxalone is available as an 800 mg oval, scored pink tablet chemically, metaxalone is 53,5 dimethylphenoxy methyl2oxazolidinone. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. Metaxalone is contraindicated in patients who have severe renal or hepatic impairment.
Metaxalone dosage for treating muscle spasms in adults and children age 12 and older, the recommended metaxalone dosage is the same. Skelaxin is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Metaxalone marketed by king pharmaceuticals under the brand name skelaxin is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Metaxalone c12h15no3 cid 15459 structure, chemical names, physical and.
Use caution in patients with renal impairment, renal disease, or other varying severities of hepatic disease. If your dose is different, do not change it unless your doctor tells you to do so. The impact of hepatic and renal disease on the pharmacokinetics pharmacokinetics in special populations dose mg the pharmacokinetics of metaxalone have been evaluated in healthy adult volunteers after 060408. This article covers just the basics on what it does, how to take it, and its potential side effects and complications. Patients with ckd are often excluded from trials, and for many medications specific studies regarding dosing and metabolism in this population are lacking. Skelaxin is a prescription medication used to treat muscle pain.
Use with caution in elderly patients and reduce dosage in patients with renal impairment. Skelaxin fda prescribing information, side effects and uses. The single dose pharmacokinetic parameters of metaxalone in two groups of healthy volunteers are shown in table 1. Pain management in patients with chronic kidney disease. Metaxalone should not be used in patients with renal failure or in those with severe hepatic disease. They are approved only for acute pain during weeks period. Skelaxin metaxalone is available as an 800 mg oval, scored pink tablet inscribed with 8667 on the scored side and s on the other. Nonetheless and generally speaking, it is a good practice to take it at less than 400 mg and titrate its dose to clinical response. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Mexalone is prescribed as an adjunct to physical therapy for the treatment of shortterm painful muscle and skeletal conditions.
The recommended dosage is 800 mg orally three to four times daily. The exact mechanism of action of metaxalone is unknown. Pain has been reported to be a common problem in the general population and endstage renal disease esrd patients. It is often taken by individuals that struggled with pressures, sprains and other type of injuries. Read more about the prescription drug metaxalone oral. It is often taken by individuals that struggled with pressures, sprains and. Metaxalone is a white to almost white, odorless crystalline powder freely soluble in chloroform, soluble in methanol and in. Renal function, or glomerular filtration rate, should be estimated by calculating creatinine clearance using the cockcroftgault equation. In conjunction with the uvar photopheresis to treat diffuse systemic sclerosis. This drug is supplied as 400mg tablets and has a recommended dose of 800 mg 3 or 4. Urinary retention is found among people who take skelaxin, especially for people who are female, 4049 old, have been taking the drug for for more details.
Drugs az pill identifier supplements symptom checker diseases dictionary media. The prescription medicine is in a class of drugs known as antiarrhythmics. Dose proportionality at doses above 800 mg has not been studied. Metaxalone may also be used for purposes not listed in this medication guide. Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Tylenol acetaminophen dosing, indications, interactions.
This drug is supplied as 400mg tablets and has a recommended dose of 800 mg 3 or. Skelaxin is a drug approved to treat muscle spasms due to injuries or other muscle problems. The renal drug handbook the st georges hospital, adult critical. For more information and to be sure skelaxin is the right drug for you, have a conversation with your doctor or pharmacist. The empirical formula is c 12 h 15 no 3, which corresponds to a molecular weight of 221. Sotalol betapace side effects, dosage, interactions drugs. Metaxalone skelaxin is a drug that relaxes the skeletal muscle. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. This emedtv web article describes how skelaxin works, explains what you should know before taking the prescription drug, and lists possible side effects. It is used to treat pain and stiffness in muscles caused by strains, sprains, or other injury. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Consumer information about the medication metaxalone oral skelaxin, includes side effects, drug interactions, recommended dosages, and storage information. This emedtv web resource highlights other skelaxin dosing guidelines, including tips on when and how to take this prescription muscle relaxant. Flexeril and skelaxin are both used as muscle relaxants and approved for shortterm treatment of different painful musculoskeletal conditions. I am at the maximum dose of topamax and i sometimes wonder how much lower my blood pressure can go when i take the inderal as i take 80mg 3x a day. Common questions and answers about skelaxin maximum dosage skelaxin the maximum dosage of ibuprofen is 2400 mg per day given in three equal dosages, but should be more of an acute dosing 23 weeks maximum. The impact of hepatic and renal disease on the pharmacokinetics of metaxalone has not been determined. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. Reglan and zofran drip coughing and norvasc irbesartan endothelium valtrex construction the socialist party of america organizations foundeds mo ccw reciprocity map is fluoxetine used for ptsd socialism of bernie sanders metronidazole 500 mg oral tablet for h. Skelaxin may also be used for purposes not listed in this medication guide. Metaxalone skelaxin is an inexpensive muscle relaxer. Sedative effects may be potentiated when used with other sedatives.
Metaxalone is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. It works by blocking nerve impulses or pain sensations in the brain. Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. Skelaxin metaxalone dosing, indications, interactions. Generic skelaxin metaxalone is a prescription muscular tissue relaxant that can be advised with bodily therapy and lots of rest. Metaxalone is contraindicated in patients with significantly impaired renal or hepatic function. Sotalol is the generic form of the brandname drug betapace, used to treat a serious irregular heartbeat. The absolute bioavailability of metaxalone is not known. Follow your doctors orders or the directions on the label.
Welcome to the fifth edition of the renal drug handbook. Indicated for acute, painful musculoskeletal conditions. Swim far prefers carisoprodol to skelaxin metaxalone, even though the patent expired years ago for both medical and recreational reasons. These work by relaxing muscles and relieving pain and discomfort caused by strains, sprains, or other muscle injuries. Metaxalone skelaxin side effects, dosage, interactions.